Antiproliferative and cytotoxic secondary metabolites from fruits of Leplaea mayombensis

• Published in: Natural product research Vol. 33; no. 5; pp. 635 - 641
• Main Authors: Lazare, Sidjui Sidjui, Désiré, Soh, Joel Ebenezer, Dameue Tegang, Brice, Happi Tchakounté, Rufin Marie, Toghueo Kouipou, Alain, Wembe Ngouonpe, Muhammad, Shaiq Ali, Gabriel, Folefoc Ngosong
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2019; Taylor & Francis Ltd
• Subjects: antiproliferative activity; Antiproliferatives; Chemical compounds; Cytotoxicity; Fruits; Leplaea mayombensis; Metabolites; Organic chemistry; seco-lanostane-type triterpene; Secondary metabolites; Selectivity; Toxicity; Triterpenes; s-lanostane-type triterpene; antiproliferative activity; cytotoxicity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2017.1402321

Two new seco-lanostane-type triterpenes, named mayomlactones A (1) and B (2) were isolated from the fruits of Leplaea mayombensis together with 10 known compounds (3-12). Structures of the new compounds were elucidated by extensive spectroscopic studies. Except compounds 11 and 12, all the other chemical compounds are newly reported from Leplaea genus. From the results of this investigation, compounds 1-10 were examined for antiproliferative activity against HeLa cells as well as cytotoxicity against 3T3 cell line. Compounds 3 and 4 showed moderate antiproliferative activity with IC 50 values of 10.4 ± 0.1 and 18.6 ± 0.2 μM, respectively. On the other hand, compounds 1, 4 and 9 showed weak cytotoxicity with IC 50 values 44.1 ± 0.5, 55.8 ± 0.7 and 55.1 ± 0.5 μM. Overall, none of the tested compounds showed good selectivity (SI ranging from 0.51 to 3.06) but high toxicity against the 3T3 cell line.