The exquisitely cooperative nature of Orai1 channel activation

Yeung and Prakriya highlight new research showing that STIM1 must bind to all six Orai1 subunits to effectively activate the channel.

Saved in:
Bibliographic Details
Published inThe Journal of general physiology Vol. 150; no. 10; pp. 1352 - 1355
Main Authors Yeung, Priscilla See-Wai, Prakriya, Murali
Format Journal Article
LanguageEnglish
Published United States Rockefeller University Press 01.10.2018
Subjects
Calcium
Calcium channels
Chemical reactions
Commentaries
Genes
Molecules
Mutation
Orai1 protein
STIM1 protein
Stoichiometry
Online AccessGet full text

Cover

More Information
Summary:Yeung and Prakriya highlight new research showing that STIM1 must bind to all six Orai1 subunits to effectively activate the channel.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Commentary-1
ISSN:0022-1295
1540-7748
DOI:10.1085/jgp.201812172