Effect of lisuride on experimental cerebral infarction in rats

Lisuride is an ergot derivative with central dopaminergic (D2 agonistic) and serotonergic (5-HT1A agonistic) activity. The effect of lisuride on experimental cerebral infarction in rats was investigated. Cerebral infarction was induced by intracarotid infusion of a 50-microliters mixture in which de...

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Bibliographic Details
Published inNihon yakurigaku zasshi Vol. 98; no. 6; p. 449
Main Authors Miyazawa, T, Murayama, C, Nakagawa, H
Format Journal Article
LanguageJapanese
Published Japan 1991
Subjects
Animals
Body Water - metabolism
Brain - metabolism
Brain - pathology
Cerebral Infarction - drug therapy
Cerebral Infarction - metabolism
Cerebral Infarction - pathology
Electrolytes - metabolism
Lisuride - therapeutic use
Male
Rats
Rats, Inbred Strains
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Summary:Lisuride is an ergot derivative with central dopaminergic (D2 agonistic) and serotonergic (5-HT1A agonistic) activity. The effect of lisuride on experimental cerebral infarction in rats was investigated. Cerebral infarction was induced by intracarotid infusion of a 50-microliters mixture in which deformed and rigid red blood cells treated with hypertonic solution were contained. Lisuride or 0.9% NaCl was administered subcutaneously 30 min before induction of cerebral infarction. Lisuride (0.01 mg/kg) not only prolonged the survival time of the animals but also suppressed cerebral edema, increase in the electrolytes content and histological damage in the brain. These results suggest that lisuride has a protective effect against cerebral infarction.
ISSN:0015-5691
DOI:10.1254/fpj.98.6_449