Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla

Six new triterpenes, uncarinic acids K-P (1-6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of o...

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Published inJournal of asian natural products research Vol. 23; no. 4; pp. 307 - 317
Main Authors Li, Ruo-Fei, Guo, Qing-Lan, Zhu, Cheng-Gen, Xu, Cheng-Bo, Wei, Ya-Zi, Cai, Jian, Wang, Yue, Sun, Hua, Zhang, Tian-Tai, Shi, Jian-Gong
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis 03.04.2021
Taylor & Francis Ltd
Subjects
Acids
Bioassays
Chemistry
Chemistry, Applied
Chemistry, Medicinal
Data analysis
Life Sciences & Biomedicine
Molecular Structure
Pharmacology & Pharmacy
Physical Sciences
Plant Extracts
Plant Sciences
Rubiaceae
Science & Technology
Stems
triterpene
Triterpenes
Uncaria
Uncaria rhynchophylla
uncarinic acids K-P
triterpene
uncarinic acids K-P
Uncaria rhynchophylla
Rubiaceae
uncarinic acids KP
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Summary:Six new triterpenes, uncarinic acids K-P (1-6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the (E)-/(Z)-coumaroyloxy and (E)-/(Z)-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2020.1870961