Cytokine profiles in an extremely preterm infant with congenital syphilis

We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supp...

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Published inFUKUSHIMA JOURNAL OF MEDICAL SCIENCE Vol. 69; no. 3; pp. 185 - 189
Main Authors Fukama, Eisuke, Nomura, Tomoaki, Hatanaka, Daisuke, Kusakari, Michiko, Takahashi, Hidehiro, Nakamura, Toshihiko, Takahashi, Naoto
Format Journal Article
LanguageEnglish
Published THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE 01.01.2023
The Fukushima Society of Medical Science
Subjects
Case Report
congenital syphilis
cytokine
IL-12
IL-17
IL-2
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Summary:We report the cytokine profiles of an infant with congenital syphilis as a first case. This female infant was born by vaginal delivery at a gestational age of 27 weeks during her mother’s treatment for syphilis. Elevation of T helper (Th)-1 cytokines (interleukin (IL)-2, IL-12) and IL-17, which supports immunological mechanisms of Th-1, was similar to that in cases of syphilis in adults. IL-6 and granulocyte colony-stimulating factor (G-CSF), the synergistic effects of which cause the leukemoid reaction, were also elevated. The levels of interferon-γ and IL-17 in cerebral spinal fluid, which are elevated in neurosyphilis in adults, were slightly elevated.
ISSN:0016-2590
2185-4610
DOI:10.5387/fms.2023-06