Prevalence of antibiotic resistance and integrons, sul and Smqnr genes in clinical isolates of Stenotrophomonas maltophilia from a tertiary care hospital in Southwest Iran

• Published in: Iranian journal of basic medical sciences Vol. 22; no. 8; pp. 872 - 877
• Main Authors: Ebrahim-Saraie, Hadi Sedigh, Heidari, Hamid, Soltani, Behnaz, Mardaneh, Jalal, Motamedifar, Mohammad
• Format: Journal Article
• Language: English
• Published: Iran Mashhad University of Medical Sciences 01.08.2019
• Subjects: Acquired immune deficiency syndrome; AIDS; Antibiotic resistance; Antibiotics; Antimicrobial agents; Bacteriology; Deoxyribonucleic acid; DNA; Drug resistance; Genes; Infections; Integrons; Medicine; Original; Pathogens; Polymerase chain reaction; Smqnr gene; Software; Stenotrophomonas maltophilia; Studies; Sul gene; Teaching hospitals; Virology; Antibiotic resistance Integrons; Smqnr gene Stenotrophomonas – maltophilia; Sul gene
• ISSN: 2008-3866; 2008-3874
• DOI: 10.22038/ijbms.2019.31291.7540

has emerged as an important opportunistic nosocomial pathogen due to its intrinsic and acquired resistance to a wide range of antimicrobial agents. The present study aimed to investigate the occurrence of antibiotic resistance and resistance mechanisms among clinical isolates of from Iranian patients. This cross-sectional study was performed on 44 isolates that were recovered from different clinical specimens in 2015 and 2016. Conventional microbiologic methods were used for primary identification of isolates and confirmed by specific polymerase chain reaction (PCR) primers. Minimum inhibitory concentrations (MICs) were determined by the E-test. PCR was applied to determine antibiotic resistance genes. All of isolates were susceptible to trimethoprim/sulfamethoxazole (TMP/SMX) and colistin. Moreover, the susceptibility rates of isolates toward ceftazidime and ciprofloxacin were 93.2%, and 84.1%, respectively. Class 1 integrons was detected in 24 (54.5%) isolates by the presence of gene. Moreover, the prevalence of antibiotic resistance genes , , and were found in 16 (36.4%), 15 (34.1%), and 29 (65.9%) isolates, respectively. In summary, the prevalence of and genes in integrons-contained isolates point out the significant risk of sulfonamides and fluoroquinolones resistance among clinical isolates of in our region.