Improvement of Dementia Screening Accuracy of Mini-Mental State Examination by Education-Adjustment and Supplementation of Frontal Assessment Battery Performance

• Published in: Journal of Korean medical science Vol. 28; no. 10; pp. 1522 - 1528
• Main Authors: Kim, Jee Wook, Lee, Dong Young, Seo, Eun Hyun, Sohn, Bo Kyung, Park, Shin Young, Choo, IL Han, Youn, Jong Chul, Jhoo, Jin Hyeong, Kim, Ki Woong, Woo, Jong Inn
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Academy of Medical Sciences 01.10.2013; 대한의학회
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - complications; Alzheimer Disease - diagnosis; Area Under Curve; Dementia - complications; Dementia - diagnosis; Demography; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Original; ROC Curve; 의학일반; Frontal Assessment Battery; Screening Accuracy; Education; Mini-Mental State Examination; Dementia
• ISSN: 1011-8934; 1598-6357; 1598-6357
• DOI: 10.3346/jkms.2013.28.10.1522

This study aimed to investigate whether the demographic variable-adjustment and supplementation of Frontal Assessment Battery (FAB) score can improve the screening ability of Mini-Mental State Examination (MMSE) for dementia and its subtypes. Five hundred forty-one non-demented comparison (NC) and 474 dementia (320 Alzheimer's disease [AD]; 139 non-Alzheimer's disease dementia [NAD]; and 15 mixed AD-NAD dementia) individuals living in the community were included. Education-adjusted MMSE (MMSE-edu) score showed significantly better screening accuracy for overall dementia, AD, and NAD than MMSE raw score. FAB-supplemented MMSE (MMSE-FAB) score had significantly better screening ability for NAD, but not for overall dementia and AD, than MMSE raw score alone. Additional supplementation of FAB to MMSE-edu further increased the ability for overall dementia or NAD screening, but not for AD screening. Further education adjustment of MMSE-FAB also improved its ability for overall dementia, AD, and NAD screening. These results strongly support the usefulness of education-adjustment and supplementation of frontal function assessment to improve screening performance of MMSE for dementia and its subtypes, NAD in particular.