Leukocyte membrane bleb and pseudopod formation in hypertension

Leukocyte activation, including adhesion molecule expression, oxygen radical generation and, in animal studies, pseudopod formation, is a hallmark of hypertension. This study examined pseudopod and bleb formation and demonstrates that leukocytes from hypertensive individuals are more susceptible to...

Full description

Saved in:
Bibliographic Details
Published inJournal of human hypertension Vol. 24; no. 10; pp. 684 - 686
Main Authors EDWARDS, K. M, SHEU, B, HONG, S, PENN, A. H, SCHMID-SCHÖNBEIN, G. W, MILLS, P. J
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.10.2010
Subjects
Adult
Apoptosis
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Case-Control Studies
Cell Membrane - pathology
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Health aspects
Humans
Hypertension
Hypertension - pathology
Hypertension - physiopathology
Leukocytes
Leukocytes - pathology
Male
Medical sciences
Middle Aged
Pseudopodia - pathology
Hypertension
Leukocyte
Cardiovascular disease
Online AccessGet full text

Cover

More Information
Summary:Leukocyte activation, including adhesion molecule expression, oxygen radical generation and, in animal studies, pseudopod formation, is a hallmark of hypertension. This study examined pseudopod and bleb formation and demonstrates that leukocytes from hypertensive individuals are more susceptible to produce membrane blebs than leukocytes from normotensive individuals. Bleb formation is likely indicative of apoptosis, thus this observation adds to previous observations of increased apoptosis in various tissues in hypertension.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
content type line 63
ObjectType-Correspondence-1
ISSN:0950-9240
1476-5527
DOI:10.1038/jhh.2010.41