Alternative total synthesis of dendrodolide-L

A new synthetic route for the total synthesis of dendrodolide-L has been developed from known chiral epoxides. The key reactions involved in this synthesis are regioselective ring-opening of epoxide, Yamaguchi esterification and ring-closing metathesis reactions (RCM) to result the target compound.

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Bibliographic Details
Published inNatural product research Vol. 34; no. 21; pp. 3089 - 3093
Main Authors Musulla, Sridhar, Bharathi Kumari, Y, Madala, Mahesh, Srinivasa Rao, A, Vema, Venkata Naresh
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.11.2020
Taylor & Francis Ltd
Subjects
Chemical synthesis
Dendrodolide-L
Epoxides
Epoxy Compounds - chemical synthesis
Epoxy Compounds - chemistry
Esterification
Lactones - chemical synthesis
Lactones - chemistry
Macrolides - chemical synthesis
Metathesis
Molecular Structure
ozonolysis
Ring opening
Stereoisomerism
Yamaguchi esterification and ring-closing metathesis
Yamaguchi esterification and ring-closing metathesis
Dendrodolide-L
ozonolysis
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Summary:A new synthetic route for the total synthesis of dendrodolide-L has been developed from known chiral epoxides. The key reactions involved in this synthesis are regioselective ring-opening of epoxide, Yamaguchi esterification and ring-closing metathesis reactions (RCM) to result the target compound.
Bibliography:ObjectType-Article-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1608543