The role and clinical implications of microRNAs in hepatocellular carcinoma

Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Sev...

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Published inScience China. Life sciences Vol. 55; no. 10; pp. 906 - 919
Main Authors Zhao, Xue, Yang, Zhen, Li, GuangBing, Li, DongKai, Zhao, Yi, Wu, Yan, Robson, Simon C., He, Lian, Xu, YiYao, Miao, RuoYu, Zhao, HaiTao
Format Journal Article
LanguageEnglish
Published Beijing Science China Press 01.10.2012
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Carcinoma, Hepatocellular - genetics
Humans
Life Sciences
Liver Neoplasms - genetics
microRNA
MicroRNAs - chemistry
miRNA
Review
临床意义
癌组织
细胞周期检查点
肝细胞癌
调控基因表达
非编码RNA
cancer therapy
miRNA
noncoding RNAs
hepatocellular carcinoma
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Abstract Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early di- agnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumor- igenesis.
AbstractList Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.[PUBLICATION ABSTRACT]
Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.
Abstract Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early diagnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumorigenesis.
Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early di- agnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumor- igenesis.
Author ZHAO Xue YANG Zhen LI GuangBing LI DongKai ZHAO Yi WU Yan ROBSON Simon C. HE Lian XU YiYao MIAO R-uoYu ZHAO HaiTao
AuthorAffiliation Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China School of Life Science, Fudan University, Shanghai 200433, China Department of Liver Transplantation and Hepatobiliary Surgery Provincial Hospital Affiliated to Shandong University, Jinan 250021, China Bioiformatics Research Group, Center for Advanced Computing Technology Research, Institute of Computing Technology, Chinese Academy o（ Sciences, Beijing 100190, China Liver Center and Transplant Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts 02215, USA
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ISSN 1674-7305
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IsDoiOpenAccess true
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Issue 10
Keywords cancer therapy
miRNA
noncoding RNAs
hepatocellular carcinoma
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c441t-b8b4e1d9630260be1e30b4ccde2aefbed810eee267e5218753358802bc0c71773
Notes Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early di- agnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumor- igenesis.
miRNA, noncoding RNAs, hepatocellular carcinoma, cancer therapy
11-5841/Q
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink http://link.springer.com/10.1007/s11427-012-4384-x
PMID 23108868
PQID 1115622109
PQPubID 54335
PageCount 14
ParticipantIDs proquest_miscellaneous_1124755115
proquest_journals_1115622109
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PublicationCentury 2000
PublicationDate 2012-10-01
PublicationDateYYYYMMDD 2012-10-01
PublicationDate_xml – month: 10
  year: 2012
  text: 2012-10-01
  day: 01
PublicationDecade 2010
PublicationPlace Beijing
PublicationPlace_xml – name: Beijing
– name: China
PublicationTitle Science China. Life sciences
PublicationTitleAbbrev Sci. China Life Sci
PublicationTitleAlternate Sci China Life Sci
PublicationYear 2012
Publisher Science China Press
Springer Nature B.V
Publisher_xml – name: Science China Press
– name: Springer Nature B.V
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Snippet Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small...
Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of small...
Abstract Hepatocellular carcinoma (HCC) is common and one of the most aggressive of all human cancers. Recent studies have indicated that miRNAs, a class of...
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pubmed
springer
chongqing
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StartPage 906
SubjectTerms Biomedical and Life Sciences
Carcinoma, Hepatocellular - genetics
Humans
Life Sciences
Liver Neoplasms - genetics
microRNA
MicroRNAs - chemistry
miRNA
Review
临床意义
癌组织
细胞周期检查点
肝细胞癌
调控基因表达
非编码RNA
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Title The role and clinical implications of microRNAs in hepatocellular carcinoma
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https://link.springer.com/article/10.1007/s11427-012-4384-x
https://www.ncbi.nlm.nih.gov/pubmed/23108868
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Volume 55
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