The role and clinical implications of microRNAs in hepatocellular carcinoma

Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Sev...

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Published inScience China. Life sciences Vol. 55; no. 10; pp. 906 - 919
Main Authors Zhao, Xue, Yang, Zhen, Li, GuangBing, Li, DongKai, Zhao, Yi, Wu, Yan, Robson, Simon C., He, Lian, Xu, YiYao, Miao, RuoYu, Zhao, HaiTao
Format Journal Article
LanguageEnglish
Published Beijing Science China Press 01.10.2012
Springer Nature B.V
Subjects
Biomedical and Life Sciences
Carcinoma, Hepatocellular - genetics
Humans
Life Sciences
Liver Neoplasms - genetics
microRNA
MicroRNAs - chemistry
miRNA
Review
临床意义
癌组织
细胞周期检查点
肝细胞癌
调控基因表达
非编码RNA
cancer therapy
miRNA
noncoding RNAs
hepatocellular carcinoma
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Summary:Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early di- agnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumor- igenesis.
Bibliography:Hepatocellular carcinoma （HCC） is common and one of the most aggressive of all human cancers. Recent studies have indi- cated that miRNAs, a class of small noncoding RNAs that regulate gene expression post-transcriptionally, directly contribute to HCC by targeting many critical regulatory genes. Several miRNAs are involved in hepatitis B or hepatitis C virus replication and virus-induced changes, whereas others participate in multiple intracellular signaling pathways that modulate apoptosis, cell cycle checkpoints, and growth-factor-stimulated responses. When disturbed, these pathways appear to result in malignant transformation and ultimately HCC development. Recently, miRNAs circulating in the blood have acted as possible early di- agnostic markers for HCC. These miRNA also could serve as indicators with respect to drug efficacy and be prognostic in HCC patients. Such biomarkers would assist stratification of HCC patients and help direct personalized therapy. Here, we summarize recent advances regarding the role of miRNAs in HCC development and progression. Our expectation is that these and ongoing studies will contribute to the understanding of the multiple roles of these small noncoding RNAs in liver tumor- igenesis.
miRNA, noncoding RNAs, hepatocellular carcinoma, cancer therapy
11-5841/Q
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-012-4384-x