Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation

• Published in: Immunity (Cambridge, Mass.) Vol. 45; no. 6; pp. 1299 - 1310
• Main Authors: Kuroda, Etsushi, Ozasa, Koji, Temizoz, Burcu, Ohata, Keiichi, Koo, Christine X., Kanuma, Tomohiro, Kusakabe, Takato, Kobari, Shingo, Horie, Masanori, Morimoto, Yasuo, Nakajima, Saeko, Kabashima, Kenji, Ziegler, Steven F., Iwakura, Yoichiro, Ise, Wataru, Kurosaki, Tomohiro, Nagatake, Takahiro, Kunisawa, Jun, Takemura, Naoki, Uematsu, Satoshi, Hayashi, Masayuki, Aoshi, Taiki, Kobiyama, Kouji, Coban, Cevayir, Ishii, Ken J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.12.2016
• Subjects: Aluminum Compounds - toxicity; alveolar macrophages; Animals; Bronchi - immunology; Female; iBALT; IgE; IL-1α; Interleukin-1alpha - immunology; Lymphoid Tissue - immunology; Macrophages, Alveolar - pathology; Mice; Mice, Inbred C57BL; Particulate; Particulate Matter - toxicity; Silicon Dioxide - toxicity; Particulate; IL-1α; IgE; iBALT; alveolar macrophages
• ISSN: 1074-7613; 1097-4180
• DOI: 10.1016/j.immuni.2016.11.010

Particulate pollution is thought to function as an adjuvant that can induce allergic responses. However, the exact cell types and immunological factors that initiate the lung-specific immune responses are unclear. We found that upon intratracheal instillation, particulates such as aluminum salts and silica killed alveolar macrophages (AMs), which then released interleukin-1α (IL-1α) and caused inducible bronchus-associated lymphoid tissue (iBALT) formation in the lung. IL-1α release continued for up to 2 weeks after particulate exposure, and type-2 allergic immune responses were induced by the inhalation of antigen during IL-1α release and iBALT formation, even long after particulate instillation. Recombinant IL-1α was sufficient to induce iBALTs, which coincided with subsequent immunoglobulin E responses, and IL-1-receptor-deficient mice failed to induce iBALT formation. Therefore, the AM-IL-1α-iBALT axis might be a therapeutic target for particulate-induced allergic inflammation. [Display omitted] •Particulates act as a long-lasting adjuvant to subsequent antigen inhalation•Particulates induce alveolar macrophage death and IL-1α release in the lung•IL-1α release in the lung is involved in iBALT formation•Tfh cells induced by direct airway sensitization are required for iBALT formation Inhaled fine particulates are known to induce allergic responses, but the exact cell types and immunological factors that initiate the lung-specific immune responses remain unclear. Kuroda et al. (2016) show that particulates trigger tertiary lymphoid organ formation in the lung as a consequence of alveolar macrophage death and IL-1α release.