Inducing secondary metabolite production from Daldinia eschscholzii JC-15 by red ginseng medium

• Published in: Natural product research Vol. 34; no. 21; pp. 3101 - 3107
• Main Authors: Wang, Bang-Yan, Yang, Ya-Bin, Yang, Xue-Qiong, Zhu, Chen-Hao, Yang, Shuang, Xu, Ting-Ting, Wang, Xue-Yin, Tan, Ning-Hua, Zhou, Hao, Ding, Zhong-Tao
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.11.2020; Taylor & Francis Ltd
• Subjects: 3T3-L1 Cells; Acetylcholinesterase; Animals; Anti-Bacterial Agents - pharmacology; Antifungal Agents - pharmacology; Antiinfectives and antibacterials; Antineoplastic Agents - pharmacology; bioactivity; Cell Line, Tumor; Cholinesterase Inhibitors - chemistry; Cholinesterase Inhibitors - metabolism; Cholinesterase Inhibitors - pharmacology; Culture Media - pharmacology; Daldinia; Daldinia eschscholzii; Diet; Dietary supplements; Drug Evaluation, Preclinical; E coli; Escherichia coli - drug effects; Fermentation; Fermented food; Fusarium - drug effects; Ginseng; Herbal medicine; Humans; Lactones - metabolism; Lactones - pharmacology; medium induction; Metabolite; Metabolites; Mice; Microbial Sensitivity Tests; Microorganisms; Molecular Structure; Naphthalene; Panax - chemistry; red ginseng; Secondary Metabolism; Xylariales - drug effects; Xylariales - metabolism; medium induction; bioactivity; red ginseng; Metabolite; Daldinia eschscholzii
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1610751

Red ginseng (RG) is one of the most popular herbal medicines and used as a dietary supplement in recent years. The bioactive ingredient in RG can induce the production of novel microbial metabolite from fermented RG. Using the one strain-many compounds strategy, the reinvestigation of the metabolites from Daldinia eschscholzii JC-15 cultured in red ginseng medium led to the isolation of an unprecedented benzopyran-naphthalene hybrid, daldinsin (1) and a new lactone (2). In this research, a new lactone, 8-hydroxylhelicascolide A (2) instead of helicascolide A was produced by the D. eschscholzii JC-15 induced by the red ginseng medium. Compound 1 showed anti-acetylcholinesterase activity with the inhibition ratio of 38.8% at 50 μM. Compound 2 indicated antimicrobial activities against Fusarium Solani, F. oxysporum, and Escherichia coli with MICs at 128 μg/mL. RG is therefore a promising activator in production of novel microbial metabolite.