A TICT based NIR-fluorescent probe for human serum albumin: a pre-clinical diagnosis in blood serum

• Published in: Chemical communications (Cambridge, England) Vol. 52; no. 6; pp. 1182 - 1185
• Main Authors: Reja, Shahi Imam, Khan, Imran A, Bhalla, Vandana, Kumar, Manoj
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2016
• Subjects: Blood; Blood plasma; blood serum; chemical reactions; Chemistry; Chemistry, Multidisciplinary; Crystallography, X-Ray; Diagnosis; Fluorescence; Fluorescent Dyes - chemistry; Human; human serum albumin; Humans; Limit of Detection; Nucleotides; Physical Sciences; Proteins; Science & Technology; Serum Albumin - analysis; Serums; Spectroscopy, Near-Infrared - methods; thiols; SQUARAINE; ACTIVATION; CHARGE-TRANSFER; BINDING

A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested. A TICT based NIR-fluorescent probe 3 has been designed and sy...