A TICT based NIR-fluorescent probe for human serum albumin: a pre-clinical diagnosis in blood serum

A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested. A TICT based NIR-fluorescent probe 3 has been designed and sy...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 52; no. 6; pp. 1182 - 1185
Main Authors Reja, Shahi Imam, Khan, Imran A, Bhalla, Vandana, Kumar, Manoj
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2016
Subjects
Blood
Blood plasma
blood serum
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Crystallography, X-Ray
Diagnosis
Fluorescence
Fluorescent Dyes - chemistry
Human
human serum albumin
Humans
Limit of Detection
Nucleotides
Physical Sciences
Proteins
Science & Technology
Serum Albumin - analysis
Serums
Spectroscopy, Near-Infrared - methods
thiols
SQUARAINE
ACTIVATION
CHARGE-TRANSFER
BINDING
Online AccessGet full text

Cover

More Information
Summary:A TICT based NIR-fluorescent probe 3 has been designed and synthesized, which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested. A TICT based NIR-fluorescent probe 3 has been designed and synthesized which selectively detects HSA with fluorescence enhancement in blood plasma with a detection limit of 11 nM among the various proteins, nucleotides and thiols tested.
Bibliography:Electronic supplementary information (ESI) available: NMR, mass, fluorescence, spectra, UV-vis spectra, docking results and theoretical calculations details. See DOI
10.1039/c5cc08217j
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c5cc08217j