Four organosulfur compounds from the seeds of Capsella bursa-pastoris and their anti-inflammatory activities

• Published in: Natural product research Vol. 37; no. 16; pp. 2688 - 2696
• Main Authors: Wei, Zhen-Zhen, Zhou, Ti-Qiang, Xia, Zi-Ming, Liu, Si-Fan, Li, Min, Zhang, Guang-Jie, Tian, Ying, Li, Bin, Wang, Lin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.08.2023; Taylor & Francis Ltd
• Subjects: anti-inflammatory activity; Capsella bursa-pastoris; Cyclooxygenase-2; Gene expression; Inflammation; Interleukin 6; Magnetic resonance spectroscopy; Nitric-oxide synthase; NMR spectroscopy; Organosulfur compounds; Seeds; sulfoxide; Capsella bursa-pastoris; NMR spectroscopy; sulfoxide; organosulfur compounds; anti-inflammatory activity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2130307

Phytochemical investigation of the seeds of Capsella bursa-pastoris led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide (1) and 11-methylsulfinyl-undecanamide (2), along with two known compounds (3 − 4), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analysing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds 1 − 4 were evaluated for their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 1 − 4 exhibited potential anti-inflammatory activities on NO release characterised by decreasing the mRNA expression levels of inducible NO synthase (iNOS), cytokines cyclooxygenase-2 (COX-2) and interleukin 6 (IL-6).