SIRT2 polymorphism rs10410544 is associated with Alzheimer's disease in a Han Chinese population

• Published in: Journal of the neurological sciences Vol. 336; no. 1; pp. 48 - 51
• Main Authors: Xia, Man, Yu, Jin-Tai, Miao, Dan, Lu, Rui-Chun, Zheng, Xue-Ping, Tan, Lan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2014
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - ethnology; Alzheimer Disease - genetics; Alzheimer's disease; Asian Continental Ancestry Group - ethnology; Asian Continental Ancestry Group - genetics; Association study; Case-Control Studies; Cohort Studies; Female; Genetic Association Studies - methods; Han Chinese population; Humans; Male; Neurology; Polymorphism; Polymorphism, Genetic - genetics; Population Surveillance - methods; Risk factor; SIRT2; Sirtuin 2 - genetics; Association study; Han Chinese population; Alzheimer's disease; SIRT2; Risk factor; Polymorphism
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2013.10.001

Abstract Sirtuin 2 (SIRT2) is a strong protein deacetylase, which is highly expressed in central nervous system. Recently, an association between SIRT2 rs10410544 polymorphism and late-onset Alzheimer's disease (LOAD) was found in the APOEε4 -negative Caucasian population. To investigate the potential association between the rs10410544 C/T polymorphism of SIRT2 and the risk of LOAD, we conducted an independent replication case–control study in a Northern Han Chinese population comprising 1133 cases and 1159 healthy controls being matched for age and gender. The results revealed that there were significant differences in genotype and allele frequencies between LOAD cases and controls (genotype P = 0.008, allele P = 0.009). When compared with the C allele, the T allele of rs10410544 demonstrated a 1.709-fold risk for developing LOAD. After stratification by apolipoprotein E ( APOE ) ε4-carrying status, only APOE ε4 noncarriers (P = 0.035, adjusted OR = 1.656, 95% CI: 1.036–2.647) showed the relation between LOAD and SIRT2 rs10410544 T allele. This study provides the evidence that the rs10410544 C/T polymorphism of SIRT2 was associated with genetic susceptibility to LOAD in a Northern Han Chinese population.