Staphylococcus aureus colonization and chronic hand eczema: a multicenter clinical trial

• Published in: Archives of Dermatological Research Vol. 311; no. 7; pp. 513 - 518
• Main Authors: Wang, Xin, Xu, Wei, Chen, Yue, Zhang, Chengzhong, Chen, Liuqing, Lu, Yan, Shi, Weimin, Li, Linfeng
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2019; Springer Nature B.V
• Subjects: Adult; Aged; Betamethasone - administration & dosage; Betamethasone - analogs & derivatives; Chronic Disease - drug therapy; Clinical trials; Colonization; Dermatologic Agents - administration & dosage; Dermatology; Drug Combinations; Eczema; Eczema - diagnosis; Eczema - drug therapy; Eczema - microbiology; Female; Hand; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Morbidity; Nuclease; Original Paper; Pathogens; Patients; Penicillin; Polymerase chain reaction; Prognosis; Public health; Severity of Illness Index; Skin Cream - administration & dosage; Skin diseases; Staphylococcal Infections - diagnosis; Staphylococcal Infections - drug therapy; Staphylococcal Infections - microbiology; Staphylococcus aureus; Staphylococcus aureus - isolation & purification; Treatment Outcome; Triclosan; Triclosan - administration & dosage; Clinical symptom scores; Chronic hand eczema; Clinical trial; Multicenter; colonization; Staphylococcus aureus colonization
• ISSN: 0340-3696; 1432-069X
• DOI: 10.1007/s00403-019-01924-x

Chronic hand eczema is a common chronic inflammatory skin disease that influences public health. Staphylococcus aureus colonization plays important roles in chronic hand eczema morbidity and progression, which also correlated to chronicity and severity of the disease. In this multicenter clinical trial, we aim to investigate the relationship between S. aureus colonization and chronic hand eczema. Eighty patient volunteers diagnosed with chronic hand eczema in 4 hospitals from 4 cities participated in this study. Staphylococcus aureus colonization was determined using Polymerase Chain Reaction and fluorescent labeling probe to rapidly detect the endemic thermostable nuclease gene nuc of S. aureus in clinical samples. All patients were treated with Halometasone Triclosan Cream for 2 weeks. The changes of clinical symptom scores were observed during the follow-up time. We found that the severity of chronic hand eczema was related to S. aureus colonization. Chronic hand eczema would remain severer than others if S. aureus colonization was not eliminated. Eliminating S. aureus colonization could provide good effectiveness in treatment of chronic hand eczema. Therefore, we make a proposal that detection and treatment of S. aureus should be considered in the clinical treatment of chronic hand eczema.