Oligoamide, a new lactam from the leaves of Angylocalyx oligophyllus

• Published in: Natural product research Vol. 33; no. 14; pp. 2011 - 2015
• Main Authors: Wakeu Kweka, Brussine Nadège, Jouda, Jean-Bosco, Foudjo Melacheu, Gertrude, Sidjui Sidjui, Lazare, Mkounga, Pierre, Lateef, Mehreen, Ali, Muhammad Shaiq, Wandji, Jean, Djama Mbazoa, Céline
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.07.2019; Taylor & Francis Ltd
• Subjects: Amides; Angylocalyx oligophyllus; Antioxidants; Antioxidants - chemistry; Antioxidants - isolation & purification; Dichloromethane; Enzyme Inhibitors - chemistry; Enzyme Inhibitors - isolation & purification; Enzyme Inhibitors - pharmacology; Fabaceae - chemistry; Infrared analysis; lactam; Lactams - chemistry; Lactams - isolation & purification; Leaves; Molecular Structure; NMR; Nuclear magnetic resonance; Plant Leaves - chemistry; Spectrum Analysis; Urease; Urease - antagonists & inhibitors; urease inhibitory activity; urease inhibitory activity; lactam
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2018.1483925

A new lactam, oligoamide (1), along with three known compounds (2-4), stigmasterol-3-O-β-D-glucopyranoside (2), formononetin (3) and (-)-pinitol (4) were isolated from the CH 2 Cl 2 /CH 3 OH (1:1) extract of the leaves of Angylocalyx oligophyllus by chromatographic separation. Their structures were elucidated on the basis of spectroscopic analysis (UV, IR, MS, 1D, and 2D NMR). Compound 1 was found to have weak antioxidant and urease inhibitory potential.