Triterpenoids and steroids from the fruiting bodies of Hexagonia tenuis and their cytotoxicity

• Published in: Natural product research Vol. 35; no. 2; pp. 251 - 256
• Main Authors: Hung, Do Xuan, Kuo, Ping-Chung, Tuan, Nguyen Ngoc, Van Trung, Hoang, Tan Thanh, Nguyen, Thi Ha, Nguyen, Long Giang, Bach, Quang Trung, Nguyen, Thi Ngan, Nguyen, Hai, Ha Viet, Lan Phuong, Doan, Quang, Dang Ngoc, Thang, Tran Dinh
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2021; Taylor & Francis Ltd
• Subjects: Analytical methods; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Cytotoxicity; Drug Screening Assays, Antitumor; Fruit bodies; Fruiting Bodies, Fungal - chemistry; fruiting body; Hep G2 Cells; Hexagonia tenuis; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Polyporaceae - chemistry; Spectrometry; Spectrometry, Mass, Electrospray Ionization; spectroscopic and spectrometric analysis; steroid; Steroid hormones; Steroids; Steroids - chemistry; Steroids - pharmacology; Toxicity; Triterpenes - chemistry; Triterpenes - pharmacology; triterpenoid; Triterpenoids; Tumor cell lines; Vietnam; Vietnam; fruiting body; triterpenoid; spectroscopic and spectrometric analysis; Hexagonia tenuis; steroid
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1624963

One new triterpenoid, hexagonin F (1) was characterized from the fruiting bodies of Hexagonia tenuis with the assistance of spectroscopic and spectrometric analytical methods. In addition, two triterpenoids and two steroids were also identified by comparison of their physical and spectroscopic data with those reported. The purified compounds were examined for their cytotoxicity against five tumor cell lines, however, only weak cytotoxicity was demonstrated.