Feeding suppression induced by intra-ventricle III infusion of 1,5-Anhydroglucitol

• Published in: Physiology & behavior Vol. 31; no. 4; pp. 493 - 502
• Main Authors: Tsutsui, K, Sakata, T, Oomura, Y, Arase, K, Fukushima, M
• Format: Journal Article
• Language: English
• Published: United States 01.01.1983
• Subjects: Animals; Chromatography, Gas; Deoxy Sugars - pharmacology; Deoxyglucose - pharmacology; Eating - drug effects; human nutrition; Injections, Intraventricular; Ion Channels - drug effects; Isomerism; Male; nutrition physiology; Rats; Rats, Inbred Strains; Sodium - metabolism; Structure-Activity Relationship; Time Factors
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/0031-9384(83)90072-0

1,5-Anhydroglucitol (1-DG) has been known as an antimetabolic glucose analogue. Using gas chromatography, 1-DG was found to be physiologically present in rat serum. In order to investigate its direct and long-term effects on feeding, 1-DG was infused during the light period into the rat third ventricle in doses of 3.0, 6.0 and 12.0 mumol/rat. Its effects were then compared to those of similarly applied 2-deoxy-D-glucose (2-DG). Following initial hyperphagia, both of these glucose-analogues produced suppressive effects on feeding during the subsequent day throughout the light and dark periods. On the third day after 2-DG injection reduction of feeding did not recover completely to the pretreatment baseline levels, but it did recover after 1-DG. Both 1-DG and 2-DG caused linear dose-related hypophagia, with the slope for 1-DG being about half of that for 2-DG. It is suggested that the delayed hypophagia which followed the initial hyperphagia produced by deoxyglucose was a result of sustained inactivation of the Na-pump due to intracellular ATP deficiency caused by accumulation of deoxy-glucose-6-phosphate.