Mutagenic damage among bronchiectasis patients attending in the pulmonology sector of a hospital in southern Brazil

• Published in: Revista da Associacao Medica Brasileira (1992) Vol. 68; no. 9; pp. 1191 - 1198
• Main Authors: Olmedo, Daniel Wenceslau Votto, Martins, Katheryne Benini, Paz, Milene Machado, Fernandes, Caroline Lopes Feijo, Silva Júnior, Flavio Manoel Rodrigues da, Ramos, Daniela Fernandes
• Format: Magazine Article
• Language: English
• Published: Brazil Associação Médica Brasileira 01.09.2022
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Brazil - epidemiology; Bronchiectasis - diagnosis; Bronchiectasis - epidemiology; Child; Hospitals; Humans; Middle Aged; Mutagens - therapeutic use; Original; Pulmonary Medicine; Young Adult; Brazil
• ISSN: 0104-4230; 1806-9282
• DOI: 10.1590/1806-9282.20220178

Bronchiectasis is a chronic respiratory disease characterized by inflammation, irreversible dilation of the bronchi, and recurrent pulmonary infections, with a high morbidity and mortality rate, but is less studied from the point of view of its prevalence and associated factors not directly related to respiratory prognosis. As it is a disease related to the exacerbation of the inflammatory process and oxidative stress, this study searched to investigate the micronucleus frequency in patients with and without bronchiectasis treated at a specialized pulmonology service in a hospital in the extreme south of Brazil. Patients with a confirmed tomographic diagnosis of bronchiectasis were defined as cases. Mutagenicity was evaluated by the micronucleus test in patients' oral mucosa cells. Data collection was performed through a questionnaire containing socioeconomic, demographic, lifestyle, and health condition information. Of the 95 patients involved in this study, 21 (22.1%) were diagnosed with bronchiectasis aged between 12 and 89 years. There was no significant difference in the frequency of micronucleus between patients with and without bronchiectasis. There was a significant positive association between age and frequency of micronucleus among patients with bronchiectasis, but this association does not occur among patients without the disease. This is the first study to investigate data on the prevalence and clinical and epidemiological aspects of this chronic disease in Brazil, especially those related to the genotoxicity outcome.