Primary acute dengue and the deletion in chemokine receptor 5 (CCR5Δ32)

• Published in: Microbes and infection Vol. 16; no. 6; pp. 518 - 521
• Main Authors: Brestovac, Brian, Halicki, Larissa A., Harris, Ryan P., Sampson, Ian, Speers, David J., Mamotte, Cyril, Williams, David
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.06.2014
• Subjects: Acute Disease; Case-Control Studies; Cysteine–cysteine chemokine receptor 5 (CCR5); Cysteine–cysteine chemokine receptor 5–32 base deletion (CCR5Δ32); Dengue - genetics; Dengue virus; Dengue virus (DENV); Flavivirus; Gene Frequency; Genetic Predisposition to Disease; Humans; Mutation; Receptors, CCR5 - genetics; Sequence Deletion; Vector; Western Australia; Western Australia; Australia; Europe; Dengue virus (DENV); Cysteine–cysteine chemokine receptor 5 (CCR5); Cysteine–cysteine chemokine receptor 5–32 base deletion (CCR5Δ32); Vector; Flavivirus
• ISSN: 1286-4579; 1769-714X
• DOI: 10.1016/j.micinf.2014.02.007

Dengue virus is a significant arboviral pathogen that is continuing to spread due to human travel and invasion of the mosquito vectors into new regions. Chemokine receptor 5 (CCR5) has a truncated 32 base pair deletion form (CCR5Δ32), which has been associated with resistance to HIV but increased severity in some flaviviral diseases. If CCR5Δ32 is associated with dengue, European carriers of this mutation may be at increased risk. In a Western Australian population with the same frequency of CCR5Δ32 (0.08) as that found in southern Europe there was no significant difference in CCR5Δ32 allele frequency between returned travellers with and without dengue (p = 0.82, OR = 0.86, 95% CI = 0.35–2.1).