Epidemiology, molecular characterization, and recombination analysis of chicken anemia virus in Guangdong province, China

Chicken anemia virus (CAV) causes severe anemia and immunosuppression in young chickens and a compromised immune response in older birds, resulting in great economic losses to the poultry industry worldwide. Here, we report the molecular epidemiology and characterization of CAV circulating in poultr...

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Bibliographic Details
Published inArchives of virology Vol. 165; no. 6; pp. 1409 - 1417
Main Authors Tan, Chen, Wang, Zhanxin, Lei, Xiaoya, Lu, Junpeng, Yan, Zhuanqiang, Qin, Jianping, Chen, Feng, Xie, Qingmei, Lin, Wencheng
Format Journal Article
LanguageEnglish
Published Vienna Springer Vienna 01.06.2020
Springer Nature B.V
Subjects
Anemia
Animals
Base Sequence
Biomedical and Life Sciences
Biomedicine
Chicken anemia virus - classification
Chicken anemia virus - isolation & purification
Chickens
China - epidemiology
Circoviridae Infections - veterinary
Circoviridae Infections - virology
Epidemiology
Genetic Variation
Genomes
Genotype
Immune response
Immunosuppression
Infectious Diseases
Medical Microbiology
Molecular Epidemiology
Original Article
Phylogeny
Poultry
Poultry Diseases - virology
Recombination
Recombination, Genetic
Sequence Analysis, DNA - veterinary
Virology
China
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Summary:Chicken anemia virus (CAV) causes severe anemia and immunosuppression in young chickens and a compromised immune response in older birds, resulting in great economic losses to the poultry industry worldwide. Here, we report the molecular epidemiology and characterization of CAV circulating in poultry in Guangdong province, China. Ninety-one of 277 chickens collected from 2016 to 2017 were CAV positive. Full-genome sequencing revealed the presence of eight separate strains. Phylogenetic analysis based on the genome sequences obtained in this study and related sequences available in the GenBank database showed that all of the CAV isolates exhibit a close relationship to each other and belong to the same genotypic group. Putative recombination events were also detected in the genomes of the newly isolated CAVs. Collectively, our findings underscore the importance of CAV surveillance and provide information that will lead to a better understanding of the evolution of CAV.
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ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-020-04604-8