Isolation and structure determination of a new marine neurotoxin from the New Zealand shellfish, Austrovenus stutchburyi

A new marine neurotoxin was isolated from a water extract of the New Zealand shellfish, Austrovenus stutchburyi, by chromatography on columns of Sephadex G-15 and LH-20, followed by reverse-phase HPLC. It was identified as (4-methoxycarbonylbutyl)trimethyl-ammonium chloride, and this was confirmed b...

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Bibliographic Details
Published inToxicon (Oxford) Vol. 32; no. 12; pp. 1672 - 1674
Main Authors Ishida, H, Nozawa, A, Nukaya, H, Tsuji, K, Kaspar, H, Berkett, N, Kosuge, T
Format Journal Article
LanguageEnglish
Published England 01.12.1994
Subjects
(4-methoxycarbonylbutyl)trimethyl-ammonium chloride
Animals
chemical structure
Chromatography, Gel
Chromatography, High Pressure Liquid
isolation
Magnetic Resonance Spectroscopy
Marine Toxins - chemistry
Marine Toxins - isolation & purification
Marine Toxins - metabolism
neurotoxins
Neurotoxins - chemistry
Neurotoxins - isolation & purification
Neurotoxins - metabolism
New Zealand
purification
Shellfish
southwest pacific
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Veneridae
New Zealand
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Summary:A new marine neurotoxin was isolated from a water extract of the New Zealand shellfish, Austrovenus stutchburyi, by chromatography on columns of Sephadex G-15 and LH-20, followed by reverse-phase HPLC. It was identified as (4-methoxycarbonylbutyl)trimethyl-ammonium chloride, and this was confirmed by synthesis.
ISSN:0041-0101
1879-3150
DOI:10.1016/0041-0101(94)90326-3