Psilostachyin, acetylated pseudoguaianolides and their analogues: Preparation and evaluation of their anti-inflammatory potential
Naturally occurring acetylated pseudoguaianolides and spirolactone psilostachyin including their analogues were synthesized and evaluated for their anti-inflammatory potential. Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structu...
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Published in | Bioorganic & medicinal chemistry letters Vol. 21; no. 16; pp. 4847 - 4851 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Amsterdam
Elsevier Ltd
15.08.2011
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Naturally occurring acetylated pseudoguaianolides and spirolactone psilostachyin including their analogues were synthesized and evaluated for their anti-inflammatory potential.
Naturally occurring acetylated pseudoguaianolides and psilostachyin including their analogues were synthesized. The structure of semi-synthetic psilostachyin was also confirmed by X-ray crystallography. The anti-inflammatory potential of all the derivatives has been evaluated through in vitro expression of TNF-α, IL-1β and IL-6 in murine neutrophils. |
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Bibliography: | http://dx.doi.org/10.1016/j.bmcl.2011.06.037 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2011.06.037 |