Changes in Virus Load Markers during AIDS-Associated Opportunistic Diseases in Human Immunodeficiency Virus-Infected Persons

• Published in: The Journal of infectious diseases Vol. 174; no. 2; pp. 401 - 403
• Main Authors: Donovan, R. M., Bush, C. E., Markowitz, N. P., Baxa, D. M., Saravolatz, L. D.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.08.1996; University of Chicago Press; Oxford University Press
• Subjects: Acquired Immunodeficiency Syndrome - complications; Acquired Immunodeficiency Syndrome - virology; Adult; AIDS; AIDS-Related Opportunistic Infections - complications; AIDS-Related Opportunistic Infections - virology; AIDS/HIV; Antigens; Biological and medical sciences; Biomarkers; Blood plasma; Concise Communications; Disease progression; Female; HIV; HIV 1; HIV Core Protein p24 - blood; HIV Core Protein p24 - genetics; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Longitudinal Studies; Male; Medical sciences; Middle Aged; Opportunistic behavior; RNA; RNA, Viral - blood; RNA, Viral - genetics; Viral diseases; Viruses; Human; Immunopathology; RNA; Retroviridae; Biological marker; AIDS; Immune deficiency; Blood plasma; Infection; Virus; Follow up study; Immunological investigation; Viral disease; Cohort study; Lentivirinae; Human immunodeficiency virus
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/174.2.401

Human immunodeficiency virus (HIV) load markers are being used increasingly to monitor disease progression and evaluate antiretroviral therapy. This study examined plasma HIV RNA and p24 antigen levels before, during, and after 15 AIDS-associated opportunistic disease events in patients with AIDS (median CD4 cell count = 65/µL). Plasma HIV RNA was detected during 13 of the 15 events (median level before an event = 21,000 copies/mL). There was an increase in the level of plasma HIV RNA with the onset of an AIDS-associated opportunistic disease during 11 of 13 events for which HIV RNA was detectable (median level during an event = 145,000 copies/mL). There was a decline in the level of HIV RNA with the recovery from disease (median level after an event = 29,700 copies/mL). In contrast, there was no consistent or significant change in p24 antigen levels or CD4 cell counts with either the onset of or recovery from an event. Clinical interpretation of plasma HIV RNA changes must take into account this reversible elevation during AIDS-associated opportunistic disease.