Type I interferonopathies: Mendelian type I interferon up-regulation

• Published in: Current opinion in immunology Vol. 32; pp. 7 - 12
• Main Author: Crow, Yanick J
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2015
• Subjects: Allergy and Immunology; Animals; Autoimmune Diseases - diagnosis; Autoimmune Diseases - drug therapy; Autoimmune Diseases - genetics; Autoimmune Diseases - metabolism; Autoimmune Diseases of the Nervous System - diagnosis; Autoimmune Diseases of the Nervous System - drug therapy; Autoimmune Diseases of the Nervous System - genetics; Autoimmune Diseases of the Nervous System - metabolism; Complement C1q - deficiency; Gene Expression Regulation; Genetic Association Studies; Humans; Interferon Type I - metabolism; Mutation; Nervous System Malformations - diagnosis; Nervous System Malformations - drug therapy; Nervous System Malformations - genetics; Nervous System Malformations - metabolism; Osteochondrodysplasias - diagnosis; Osteochondrodysplasias - drug therapy; Osteochondrodysplasias - genetics; Osteochondrodysplasias - metabolism; Phenotype; Proteasome Endopeptidase Complex - genetics; Proteasome Endopeptidase Complex - metabolism; Signal Transduction; STAT1 Transcription Factor - genetics; STAT1 Transcription Factor - metabolism; Up-Regulation

Highlights • Uncontrolled up-regulation of type I interferon signaling can cause human disease. • Human monogenic type I interferonopathies are being increasingly recognized. • Therapies will likely become available to control type I interferon up-regulation.