Type I interferonopathies: Mendelian type I interferon up-regulation
Highlights • Uncontrolled up-regulation of type I interferon signaling can cause human disease. • Human monogenic type I interferonopathies are being increasingly recognized. • Therapies will likely become available to control type I interferon up-regulation.
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| Published in | Current opinion in immunology Vol. 32; pp. 7 - 12 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2015
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Highlights • Uncontrolled up-regulation of type I interferon signaling can cause human disease. • Human monogenic type I interferonopathies are being increasingly recognized. • Therapies will likely become available to control type I interferon up-regulation. |
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| AbstractList | The concept of grouping Mendelian disorders associated with an up-regulation of type I interferon has only recently been suggested. Here we discuss the progress being made in the delineation and understanding of this novel set of inborn errors of immunity, the human type I interferonopathies. •Uncontrolled up-regulation of type I interferon signaling can cause human disease.•Human monogenic type I interferonopathies are being increasingly recognized.•Therapies will likely become available to control type I interferon up-regulation. The concept of grouping Mendelian disorders associated with an up-regulation of type I interferon has only recently been suggested. Here we discuss the progress being made in the delineation and understanding of this novel set of inborn errors of immunity, the human type I interferonopathies. Highlights • Uncontrolled up-regulation of type I interferon signaling can cause human disease. • Human monogenic type I interferonopathies are being increasingly recognized. • Therapies will likely become available to control type I interferon up-regulation. |
| Author | Crow, Yanick J |
| Author_xml | – sequence: 1 fullname: Crow, Yanick J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25463593$$D View this record in MEDLINE/PubMed |
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| Snippet | Highlights • Uncontrolled up-regulation of type I interferon signaling can cause human disease. • Human monogenic type I interferonopathies are being... •Uncontrolled up-regulation of type I interferon signaling can cause human disease.•Human monogenic type I interferonopathies are being increasingly... The concept of grouping Mendelian disorders associated with an up-regulation of type I interferon has only recently been suggested. Here we discuss the... |
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| StartPage | 7 |
| SubjectTerms | Allergy and Immunology Animals Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoimmune Diseases of the Nervous System - diagnosis Autoimmune Diseases of the Nervous System - drug therapy Autoimmune Diseases of the Nervous System - genetics Autoimmune Diseases of the Nervous System - metabolism Complement C1q - deficiency Gene Expression Regulation Genetic Association Studies Humans Interferon Type I - metabolism Mutation Nervous System Malformations - diagnosis Nervous System Malformations - drug therapy Nervous System Malformations - genetics Nervous System Malformations - metabolism Osteochondrodysplasias - diagnosis Osteochondrodysplasias - drug therapy Osteochondrodysplasias - genetics Osteochondrodysplasias - metabolism Phenotype Proteasome Endopeptidase Complex - genetics Proteasome Endopeptidase Complex - metabolism Signal Transduction STAT1 Transcription Factor - genetics STAT1 Transcription Factor - metabolism Up-Regulation |
| Title | Type I interferonopathies: Mendelian type I interferon up-regulation |
| URI | https://www.clinicalkey.es/playcontent/1-s2.0-S0952791514001290 https://dx.doi.org/10.1016/j.coi.2014.10.005 https://www.ncbi.nlm.nih.gov/pubmed/25463593 https://search.proquest.com/docview/1672094675 https://search.proquest.com/docview/1762372109 |
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