Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against...

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Bibliographic Details
Published inMarine drugs Vol. 4; no. 1; pp. 9 - 14
Main Authors Wakuda, Yusuke, Kubota, Takaaki, Shima, Hiroshi, Okada, Tadashi, Mitsuhashi, Shinya, Aoki, Naohito, Kikuchi, Kunimi, Kobayashi, Jun'ichi
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.03.2006
Molecular Diversity Preservation International (MDPI)
Subjects
Inhibitors
Manzamenones
Marine
Plakortis
Protein tyrosine phosphatases
Short Communication
TCPTP
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Summary:Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against TCPTP was 4 times more potent than that against protein tyrosine phosphatase-1B (PTP1B).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1660-3397
1660-3397
DOI:10.3390/md401009