Adenosine and extracellular volume in radiocontrast media-induced nephropathy

• Published in: Kidney international Vol. 54; no. S67; pp. S192 - S194
• Main Authors: Erley, Christiane M., Heyne, N., Rossmeier, S., Vogel, T., Risler, Teut, Osswald, Hartmut
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.1998
• Subjects: 3-dipropylxanthine; 8-cyclopropyl-1; Acute Kidney Injury - chemically induced; Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; acute renal failure; adenosine; Adenosine - analysis; Animals; Blood Pressure; Contrast Media - adverse effects; Enzyme Inhibitors; Extracellular Space - chemistry; glomerular filtration rate; Hematocrit; hydration; Hypertension, Renal - chemically induced; Hypertension, Renal - drug therapy; Hypertension, Renal - metabolism; Kidney - chemistry; Kidney - metabolism; Male; mean arterial pressure; NG-Nitroarginine Methyl Ester; nitric oxide; nitro-L-Arg methyl ester; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; renal blood flow; Water - metabolism; Xanthines - pharmacology; adenosine; nitric oxide; acute renal failure; nitro-L-Arg methyl ester; glomerular filtration rate; hydration; renal blood flow; mean arterial pressure; 8-cyclopropyl-1; 3-dipropylxanthine

Adenosine and extracellular volume in radiocontrast media-induced nephropathy. Renal hemodynamic changes could play a key role in radiocontrast media-induced nephropathy (RCIN), although the pathophysiological mechanisms are unclear. We investigated the role of adenosine in RCIN caused by sodium dia...