Pseudocercones A-C, three new polyketide derivatives from the endophytic fungus Pseudocercospora sp. TSS-1

• Published in: Natural product research Vol. 38; no. 7; pp. 1248 - 1255
• Main Authors: Peng, Wei-Wei, Kuang, Min, Huang, Yuan-Tao, Li, Mei-Fang, Zheng, Yu-Ting, Xu, Li, Tan, Jian-Bing, Kang, Feng-Hua, Tan, Hai-Bo, Zou, Zhen-Xing
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.04.2024; Taylor & Francis Ltd
• Subjects: Antibacterial activity; Circular dichroism; Dichroism; E coli; Endophytes; endophytic fungi; Fungi; Microorganisms; NMR; Nuclear magnetic resonance; Polyketides; Pseudocercospora sp. TSS-1; structure elucidation; antibacterial activity; Pseudocercospora sp. TSS-1; structure elucidation; polyketides; endophytic fungi
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2138874

Chemical investigation of an EtOAc extract of the endophytic fungus Pseudocercospora sp. TSS-1 led to the isolation of three new polyketide derivatives, including one benzophenon derivative (1), two spirocyclic polyketides (4 and 5), along with four known compounds (2, 3, 6 and 7). Their structures and the absolute configurations were characterized by means of NMR, HRESIMS, 13 C NMR and theoretical electronic circular dichroism calculations. Furthermore, all compounds were evaluated for their antibacterial activity against four microbial pathogens (Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli), and compounds 1, 2, 3 and 5 displayed significant selective antibacterial activity against S. aureus with MIC values ranging from 3.9 to 7.8 µg/mL.