The chemical biology of ubiquitin

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 3; p. 130079
• Main Author: Burslem, George M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2022
• Subjects: Animals; Chemical biology; Humans; Polyubiquitin - chemistry; Polyubiquitin - metabolism; proteasome endopeptidase complex; Proteasome Endopeptidase Complex - chemistry; Proteasome Endopeptidase Complex - metabolism; Protein synthesis; Ubiquitin; Ubiquitin - metabolism; Ubiquitination; Chemical biology; Ubiquitin; Protein synthesis
• ISSN: 0304-4165; 1872-8006; 1872-8006
• DOI: 10.1016/j.bbagen.2021.130079

This mini-review will cover the various chemical biology approaches employed to prepare and modulate ubiquitin chains and the ubiquitin-proteasome system. Emphasis will be given to the biochemistry and chemical biology of poly-ubiquitin chain preparation as a tool to elucidate its roles in biological systems as well as the hijacking of the ubiquitin proteasome system using heterobifunctional compounds to induce intracellular ubiquitination. •Ubiquitination is a diverse and critical to understand post-translational modification.•Chemical biology approaches provide unique opportunities to prepare and study polyubiquitin chains.•Novel tools are emerging for the control of ubiquitination inside mammalian cells.