Polymorphisms in the folate-metabolizing genes MTR , MTRR, and CBS and breast cancer risk

Abstract Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes – A2756G MTR , A66G MTRR , and 844...

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Published inCancer epidemiology Vol. 36; no. 2; pp. e95 - e100
Main Authors Weiner, Alexandra S, Boyarskikh, Uljana A, Voronina, Elena N, Selezneva, Inna A, Sinkina, Tatiana V, Lazarev, Alexandr F, Petrova, Valentina D, Filipenko, Maxim L
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.04.2012
Elsevier Limited
Subjects
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - genetics
Breast cancer
Breast Neoplasms - genetics
Cancer
Cystathionine beta-Synthase - genetics
DNA methylation
Epidemiology
Female
Ferredoxin-NADP Reductase - genetics
Folate-metabolizing genes
Folic Acid - metabolism
Genetic Predisposition to Disease - genetics
Genotype
Hematology, Oncology and Palliative Medicine
Humans
Internal Medicine
Medical research
Meta-analysis
Middle Aged
Mortality
Polymorphism
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Real-Time Polymerase Chain Reaction
Risk Factors
SNP
Studies
Russia
Breast cancer
SNP
Folate-metabolizing genes
Meta-analysis
Polymorphism
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Summary:Abstract Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes – A2756G MTR , A66G MTRR , and 844ins68 CBS – which have putative functional significance in breast cancer risk. The allele and genotype frequencies of the SNPs were determined in a case group (840 women with sporadic breast cancer) and a control group (770 women). No statistically significant association of studied SNPs with breast cancer was revealed. A meta-analysis, which included data obtained from the literature and the present research, did not reveal any statistically significant associations of these SNPs with breast cancer. The results obtained provide evidence that these SNPs are not involved in the development of breast cancer.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2011.11.010