Aortic Stiffness as a Surrogate Endpoint to Micro- and Macrovascular Complications in Patients with Type 2 Diabetes

• Published in: International journal of molecular sciences Vol. 17; no. 12; p. 2044
• Main Authors: Cardoso, Claudia R L, Salles, Gil F
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.12.2016; MDPI
• Subjects: arterial stiffness; Arteries - physiopathology; Cardiovascular disease; carotid-femoral pulse wave velocity; Coronary vessels; Diabetes; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - physiopathology; Female; Humans; Hypertension; Male; microvascular and macrovascular complications; Pulse Wave Analysis; Review; type 2 diabetes; Vascular Stiffness - physiology; arterial stiffness; type 2 diabetes; microvascular and macrovascular complications; carotid-femoral pulse wave velocity
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms17122044

Increased aortic stiffness has been recognized as a predictor of adverse cardiovascular outcomes in some clinical conditions, such as in patients with arterial hypertension and end-stage renal disease, in population-based samples and, more recently, in type 2 diabetic patients. Patients with type 2 diabetes have higher aortic stiffness than non-diabetic individuals, and increased aortic stiffness has been correlated to the presence of micro- and macrovascular chronic diabetic complications. We aimed to review the current knowledge on the relationships between aortic stiffness and diabetic complications, their possible underlying physiopathological mechanisms, and their potential applications to clinical type 2 diabetes management.