Where and when should natural killer cells be tested in women with repeated implantation failure?

Highlights • Natural killer (NK) cells are increased in idiopathic repeated implantation failure (RIF). • This is found both in blood and in endometrium. • The association between NK cells and implantation failure is stronger in endometrium. • There is a positive correlation between blood and endome...

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Bibliographic Details
Published inJournal of reproductive immunology Vol. 108; pp. 142 - 148
Main Authors Santillán, Isabel, Lozano, Ignacio, Illán, Julia, Verdú, Victoria, Coca, Santiago, Bajo-Arenas, Jose Manuel, Martinez, Felipe
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.04.2015
Subjects
Abortion, Habitual - diagnosis
Abortion, Habitual - immunology
Adult
CD56
CD56 Antigen - metabolism
Cell Separation
Embryo Implantation
Embryo Transfer
Endometrium
Endometrium - pathology
Female
Flow Cytometry
Humans
Immunohistochemistry
Implantation
Killer Cells, Natural - immunology
Lymphocyte Subsets - immunology
Natural killer cells
Obstetrics and Gynecology
Prospective Studies
Receptors, IgG - metabolism
Treatment Failure
Immunohistochemistry
natural killer
h.p.f
repeated implantation failure
Implantation
high power fields of 400× magnification
Natural killer cells
NK
CD56
RIF
Endometrium
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Summary:Highlights • Natural killer (NK) cells are increased in idiopathic repeated implantation failure (RIF). • This is found both in blood and in endometrium. • The association between NK cells and implantation failure is stronger in endometrium. • There is a positive correlation between blood and endometrial levels. • In women with other types of RIF no differences are found.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0165-0378
1872-7603
DOI:10.1016/j.jri.2014.12.009