Regulation of T cell signaling and autoimmunity by RNA-binding proteins
Highlights • Roquin and Regnase-1 regulate shared mRNA targets via stem-loops in their 3′ UTRs. • Roquin and Regnase-1 are inactivated by MALT1 cleavage upon T cell stimulation. • Accessibility and affinity/avidity of cis -elements determines their responsiveness. • TCR strength is translated into d...
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Published in | Current opinion in immunology Vol. 39; pp. 127 - 135 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.04.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Roquin and Regnase-1 regulate shared mRNA targets via stem-loops in their 3′ UTRs. • Roquin and Regnase-1 are inactivated by MALT1 cleavage upon T cell stimulation. • Accessibility and affinity/avidity of cis -elements determines their responsiveness. • TCR strength is translated into differential expression of Roquin/Regnase-1 targets. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/j.coi.2016.01.011 |