Regulation of T cell signaling and autoimmunity by RNA-binding proteins

Highlights • Roquin and Regnase-1 regulate shared mRNA targets via stem-loops in their 3′ UTRs. • Roquin and Regnase-1 are inactivated by MALT1 cleavage upon T cell stimulation. • Accessibility and affinity/avidity of cis -elements determines their responsiveness. • TCR strength is translated into d...

Full description

Saved in:
Bibliographic Details
Published inCurrent opinion in immunology Vol. 39; pp. 127 - 135
Main Authors Jeltsch, Katharina M, Heissmeyer, Vigo
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2016
Subjects
Allergy and Immunology
Animals
Autoimmunity - immunology
Cell Differentiation
Humans
RNA-Binding Proteins - physiology
Signal Transduction - physiology
T-Lymphocytes - immunology
Online AccessGet full text

Cover

More Information
Summary:Highlights • Roquin and Regnase-1 regulate shared mRNA targets via stem-loops in their 3′ UTRs. • Roquin and Regnase-1 are inactivated by MALT1 cleavage upon T cell stimulation. • Accessibility and affinity/avidity of cis -elements determines their responsiveness. • TCR strength is translated into differential expression of Roquin/Regnase-1 targets.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2016.01.011