Application of Various Delivery Methods for CRISPR/dCas9

As gene-editing technology has become more and more popular in the life sciences, CRISPR has brought good news to scientific researchers because of its efficiency, convenience, and wide application. Its wide application has also promoted the development of basic scientific research, agriculture, bas...

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Bibliographic Details
Published inMolecular biotechnology Vol. 62; no. 8; pp. 355 - 363
Main Authors Liu, Zhixi, Liao, Zhi, Chen, Yan, Han, Lizhu, Yin, Qinan, Xiao, Hongtao
Format Journal Article
LanguageEnglish
Published New York Springer US 01.08.2020
Springer Nature B.V
Subjects
Animals
Biochemistry
Biological Techniques
Biotechnology
Cell Biology
Chemistry
Chemistry and Materials Science
CRISPR
CRISPR-Cas Systems
Drug Carriers
Drug Delivery Systems
Electroporation
Gene Editing
Genetic modification
Genetic Vectors
Genome editing
Human Genetics
Humans
Mice
Organs
Protein Science
Review
CRISPR
dCas9
Delivery
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Summary:As gene-editing technology has become more and more popular in the life sciences, CRISPR has brought good news to scientific researchers because of its efficiency, convenience, and wide application. Its wide application has also promoted the development of basic scientific research, agriculture, basic medicine, and clinical treatment. However, how the CRISPR/dCas9 system is effectively delivered to the target organs or cells is still unknown. This paper briefly introduces the CRISPR/dCas9 system and then lists some common delivery methods and their characteristics.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1073-6085
1559-0305
DOI:10.1007/s12033-020-00258-8