Effects of chronic restraint stress in the prostate of prepubertal and adult rats
To investigate the effects of chronic stress in the prostate of prepubertal and adult rats. Thirty-two male rats were assigned into four groups depending on the type of treatment (control or stressed) and the age at which stress was initiated (prepubertal or adult). Restraint stress stimuli were app...
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Published in | Acta Cirúrgica Brasileira Vol. 38; p. e387123 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Brazil
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
01.01.2023
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Subjects | |
Online Access | Get full text |
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Summary: | To investigate the effects of chronic stress in the prostate of prepubertal and adult rats.
Thirty-two male rats were assigned into four groups depending on the type of treatment (control or stressed) and the age at which stress was initiated (prepubertal or adult). Restraint stress stimuli were applied for six weeks. Stressed prepubertal and adult rats evaluated immediately after the last stress stimuli were named SP and SA groups, respectively. Age-matched rats were used as control groups (CP and CA). At the end of the experiment, the rats were euthanized, and prostate morphological parameters were evaluated and statistically compared.
Application of stress stimuli to the SP group resulted in reduced body weight, but no prostate morphological modification was noted. The SA group showed reduced testosterone level and prostatic epithelium surface density, in comparison to CA group. Further, the prostatic lumen surface density was increased in adult stressed animals, in comparison to adult controls.
The stress stimuli promoted changes in hormonal and morphological parameters in the prostate of adult stressed rats. Prepubertal stressed animals did not presented modifications of prostate morphology. |
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Bibliography: | About the authors: Procópio IM is master. Conflict of interest: Nothing to declare. Ribeiro CT, Marcho RG, Costa WS, Buys-Gonçalves GF, Sampaio FJB, Pereira-Sampaio MA and de Souza DB are PhDs. |
ISSN: | 0102-8650 1678-2674 |
DOI: | 10.1590/acb387123 |