Intra-Tissue Pressure Measurement in Ex Vivo Liver Undergoing Laser Ablation with Fiber-Optic Fabry-Perot Probe

• Published in: Sensors (Basel, Switzerland) Vol. 16; no. 4; p. 544
• Main Authors: Tosi, Daniele, Saccomandi, Paola, Schena, Emiliano, Duraibabu, Dinesh Babu, Poeggel, Sven, Leen, Gabriel, Lewis, Elfed
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI 15.04.2016; MDPI AG
• Subjects: ablation of tissue; Animals; Fabry-Perot; fiber optic sensors; Fiber Optic Technology - methods; Interferometry; Laser Therapy; Liver - physiology; Optical Fibers; Pressure; pressure measurement; Swine; Fabry-Perot; fiber optic sensors; ablation of tissue; pressure measurement
• ISSN: 1424-8220; 1424-8220
• DOI: 10.3390/s16040544

We report the first-ever intra-tissue pressure measurement performed during 1064 nm laser ablation (LA) of an ex vivo porcine liver. Pressure detection has been performed with a biocompatible, all-glass, temperature-insensitive Extrinsic Fabry-Perot Interferometry (EFPI) miniature probe; the proposed methodology mimics in-vivo treatment. Four experiments have been performed, positioning the probe at different positions from the laser applicator tip (from 0.5 mm to 5 mm). Pressure levels increase during ablation time, and decrease with distance from applicator tip: the recorded peak parenchymal pressure levels range from 1.9 kPa to 71.6 kPa. Different pressure evolutions have been recorded, as pressure rises earlier in proximity of the tip. The present study is the first investigation of parenchymal pressure detection in liver undergoing LA: the successful detection of intra-tissue pressure may be a key asset for improving LA, as pressure levels have been correlated to scattered recurrences of tumors by different studies.