Assessment of the Antithrombogenicity of a Poly-2-Methoxyethylacrylate-Coated Central Venous Port-Catheter System

• Published in: Cardiovascular and interventional radiology Vol. 43; no. 5; pp. 775 - 780
• Main Authors: Kariya, Shuji, Nakatani, Miyuki, Ono, Yasuyuki, Maruyama, Takuji, Ueno, Yutaka, Komemushi, Atsushi, Tanigawa, Noboru
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2020; Springer Nature B.V
• Subjects: Cardiology; Catheters; Coating; Coatings; Expulsion; Flushing; Imaging; Laboratory Investigation; Medical instruments; Medicine; Medicine & Public Health; Nuclear Medicine; Occlusion; Proteins; Radiology; Thrombosis; Ultrasound; Complication; Coating; Poly-2-methoxyethylacrylate; Antithrombogenicity; Thrombosis; Port
• ISSN: 0174-1551; 1432-086X
• DOI: 10.1007/s00270-020-02408-6

Purpose The purpose of this study was to evaluate the antithrombogenic effects of poly-2-methoxyethylacrylate (PMEA) coating applied to the internal surfaces of the port-catheter system to prevent thrombotic occlusion. Materials and Methods PMEA coating was applied to the inner surfaces of the entire system, including the chamber, catheter, and connecting stem. PMEA-coated and uncoated port-catheter systems were each filled with fresh human blood for 1 or 3 h and then flushed with saline. Volumes of residual thrombi in the system and protein in the catheter were then compared. Results Saline flushing of the PMEA-coated port-catheter system expelled all visually recognizable thrombi, leaving no unremovable adhesions. In contrast, the uncoated port showed thrombi adherent to the inner surfaces and incomplete expulsion with flushing. Mean (± standard deviation) residual thrombus mass was significantly lower in PMEA-coated port-catheter systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p  < 0.01). Mean residual protein was likewise significantly lower in PMEA-coated systems (20.5 ± 6.2 mg) than in uncoated systems (230.3 ± 92.5 mg; p  < 0.01). Conclusions PMEA coating on a central venous port-catheter system decreased accumulation and facilitated flushing of thrombi from the system by flushing, as compared with the uncoated system. PMEA-coated central venous port-catheter systems appear relatively antithrombotic compared to uncoated systems.