Acrepyrone A, a new γ-pyrone derivative from an endophytic fungus, Acremonium citrinum SS-g13

• Published in: Natural product research Vol. 34; no. 8; pp. 1091 - 1096
• Main Authors: Peng, Xiao-Ping, Li, Gang, Ji, Li-Xia, Li, Ying-Xia, Lou, Hong-Xiang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.04.2020; Taylor & Francis Ltd
• Subjects: Acremonium - chemistry; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial activity; bioactivities; Cytotoxicity; Cytotoxins - chemistry; Cytotoxins - isolation & purification; Cytotoxins - pharmacology; Endophytes; Endophytes - chemistry; Fungi; Herbal medicine; Humans; Medicinal plants; Molecular Structure; natural products; NMR; Nuclear magnetic resonance; Plant Roots - drug effects; Plants, Medicinal - microbiology; Pyrones - chemistry; Pyrones - isolation & purification; Quorum sensing; Quorum Sensing - drug effects; γ-pyrone derivative; Endophytes; natural products; γ-pyrone derivative; bioactivities
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2018.1548462

A new γ-pyrone derivative, acrepyrone A (1), and three known sorbicillinoids, trichodimerol (2), dihydrotrichodimerol (3) and tetrahydrotrichodimerol (4) were isolated from an endophytic fungus, Acremonium citrinum SS-g13, harboured in the roots of the Chinese medicinal plant Fructus mori. Their structures were determined by analysing MS, NMR, and ECD data. Compound 1 was evaluated for its cytotoxic effect, antibacterial activity and quorum sensing inhibitory potential.