Evaluation of risk classifications for gastrointestinal stromal tumor using multi-parameter Magnetic Resonance analysis

• Published in: Abdominal imaging Vol. 46; no. 4; pp. 1506 - 1518
• Main Authors: Zheng, Tao, Du, Juan, Yang, Linsha, Dong, Yanchao, Wang, Zhanqiu, Liu, Defeng, Wu, Shuo, Shi, Qinglei, Wang, Xiaohan, Liu, Lanxiang
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer Nature B.V
• Subjects: Accuracy; Classification; Diagnostic systems; Diffusion coefficient; Evaluation; Gastric cancer; Gastroenterology; Gastrointestinal cancer; Gastrointestinal system; Gastrointestinal tract; Hepatology; Hollow Organ GI; Image contrast; Image enhancement; Imaging; Indexes (ratios); Magnetic resonance imaging; Malignancy; Mathematical analysis; Medical diagnosis; Medical imaging; Medicine; Medicine & Public Health; Mesenchyme; Parameters; Radiology; Risk assessment; Risk groups; Sensitivity analysis; Soft tissues; Surgery; Tumors
• ISSN: 2366-004X; 2366-0058
• DOI: 10.1007/s00261-020-02813-y

Background Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of the gastrointestinal tract. At present, it is generally believed that the prognosis of GIST is closely related to its risk classification. It may add value to correctly diagnose and evaluate the risk of invasion using a noninvasive imaging examination prior to surgery. MRI has the advantages of multiple parameters and high soft tissue resolution, which may be the potential method to preoperatively evaluate the risk of GIST. Purpose To retrospectively evaluate the diagnostic accuracy of multi-parameter MR analysis for preoperative risk classification of GIST. Materials and methods In this 6-year retrospective study, full MRI examination was performed on all 60 GIST cases confirmed classified by pathology, including 35 cases of very low-to-low-risk GIST and 25 cases of intermediate-to-high-risk GIST. Dynamic contrast-enhanced T1- and T2-weighted images, and apparent diffusion coefficient (ADC) maps were reviewed independently by two radiologists blinded to pathologic results. Volume, ADC ratio, three wash-in indexes (WII) were calculated and compared using t-test or Kruskal–Wallis nonparametric test. Sensitivity and specificity analyses were performed to calculate diagnostic accuracy using ROC analyses. Differences were considered significant at p  < 0.05. Results All GISTs were resected. Patient age, sex, tumor location and tumor shape did not differ significantly across the two groups ( p  = 0.798, 0.767, 0.822 and 0.096, respectively). GIST in the intermediate-to-high-risk group presented significantly greater volume ( p  = 0.0045), lower ADC ratio ( p  = 0.0125) and faster enhancement (for WII2, p  < 0.0001; for WII3, p  = 0.0358) than that of GIST in the very low-to-low-risk group. This combination of the volume, ADC ratio and WII2 provided sensitivity of 88%, specificity of 94.29%, and accuracy of 91.7% for the risk classification of GIST. Conclusion Multi-parameter MR analysis provides a preoperative imaging standard for accurately distinguishing very low-to-low-risk GIST from intermediate-to-high-risk GIST.