Subject-Specific Modeling of EEG-fNIRS Neurovascular Coupling by Task-Related Tensor Decomposition

• Published in: IEEE transactions on neural systems and rehabilitation engineering Vol. 32; pp. 452 - 461
• Main Authors: Lin, Jianeng, Lu, Jiewei, Shu, Zhilin, Han, Jianda, Yu, Ningbo
• Format: Journal Article
• Language: English
• Published: United States The Institute of Electrical and Electronics Engineers, Inc. (IEEE) 2024; IEEE
• Subjects: Coupling; Decomposition; EEG; EEG-fNIRS; Electroencephalography; Electroencephalography - methods; Gamma function; hemodynamic response function; Hemodynamic responses; Hemodynamics; Hemodynamics - physiology; Humans; Infrared spectra; Infrared spectroscopy; Mathematical models; Medical imaging; Modelling; Near infrared radiation; Neurovascular coupling; Neurovascular Coupling - physiology; Parameter estimation; Reproducibility of Results; Response functions; Spectroscopy; Spectroscopy, Near-Infrared - methods; subject-specific optimization; task-related component analysis; tensor decomposition; Tensors
• ISSN: 1534-4320; 1558-0210; 1558-0210
• DOI: 10.1109/TNSRE.2024.3355121

Neurovascular coupling (NVC) connects neural activity with hemodynamics and plays a vital role in sustaining brain function. Combining electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) is a promising way to explore the NVC. However, the high-order property of EEG data and variability of hemodynamic response function (HRF) across subjects have not been well considered in existing NVC studies. In this study, we proposed a novel framework to enhance the subject-specific parametric modeling of NVC from simultaneous EEG-fNIRS measurement. Specifically, task-related tensor decomposition of high-order EEG data was performed to extract the underlying connections in the temporal-spectral-spatial structures of EEG activities and identify the most relevant temporal signature within multiple trials. Subject-specific HRFs were estimated by parameters optimization of a double gamma function model. A canonical motor task experiment was designed to induce neural activity and validate the effectiveness of the proposed framework. The results indicated that the proposed framework significantly improves the reproducibility of EEG components and the correlation between the predicted hemodynamic activities and the real fNIRS signal. Moreover, the estimated parameters characterized the NVC differences in the task with two speeds. Therefore, the proposed framework provides a feasible solution for the quantitative assessment of the NVC function.