Vascular Lesions: GLUT-1 Expression as a Diagnostic Tool to Discriminate Tumors From Malformations

Vascular lesions constitute a widely heterogeneous group of tumors and malformations. For head and neck vascular anomalies, most studies have not attempted to make the differential diagnosis between true hemangiomas and vascular malformations, because an accurate diagnosis remains a challenge for ph...

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Published inJournal of oral and maxillofacial surgery Vol. 70; no. 10; pp. 2333 - 2342
Main Authors Patiño-Seijas, Beatriz, MD, Lorenzo-Franco, Fernanda, MD, Rey-Sanjurjo, José Luis, MD, González-Cuesta, Margarita, MD, López-Cedrún Cembranos, José Luis, MD, PhD, DDS
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.10.2012
Elsevier
Subjects
Biological and medical sciences
Biomarkers - analysis
Capillaries - pathology
Dentistry
Diagnosis, Differential
Female
Fibrosis
Glucose Transporter Type 1 - analysis
Hemangioma - diagnosis
Hemangioma, Cavernous - diagnosis
Humans
Hypertrophy
Male
Masseter Muscle - blood supply
Masseter Muscle - pathology
Medical sciences
Middle Aged
Muscle Neoplasms - diagnosis
Muscle, Smooth, Vascular - pathology
Otorhinolaryngology. Stomatology
Surgery
Vascular Malformations - diagnosis
Young Adult
Treatment
Malformation
Stomatology
Surgery
Blood vessel
Tumor
Diagnosis
Lesion
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Summary:Vascular lesions constitute a widely heterogeneous group of tumors and malformations. For head and neck vascular anomalies, most studies have not attempted to make the differential diagnosis between true hemangiomas and vascular malformations, because an accurate diagnosis remains a challenge for physicians. The successful treatment of vascular anomalies depends on a profound knowledge of their biologic behavior and correct classification. Recently, specific immunohistochemical markers such as erythrocyte-type glucose transporter protein 1 have been described to differentiate hemangiomas from vascular malformations. This report describes 2 cases of intramuscular vascular anomalies involving the masseter muscle histologically diagnosed primarily as cavernous hemangiomas and presents the imaging and pathologic findings. Ample surgical excision was performed through an intraoral approach. Immunohistochemistry showed no uptake of glucose transporter protein 1. The literature was reviewed and the designation intramasseteric vascular malformation for this entity is proposed.
Bibliography:ObjectType-Case Study-3
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ISSN:0278-2391
1531-5053
DOI:10.1016/j.joms.2011.11.013