Two new phthalide derivatives from the endophytic fungus Penicillium vulpinum isolated from Sophora tonkinensis

• Published in: Natural product research Vol. 35; no. 3; pp. 421 - 427
• Main Authors: Qin, Yuyue, Liu, Xiaobo, Lin, Jing, Huang, Jingying, Jiang, Xiaofei, Mo, Tuxiang, Xu, Zhaolong, Li, Jun, Yang, Ruiyun
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2021; Taylor & Francis Ltd
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Bacillus subtilis - drug effects; Benzofurans - chemistry; Benzofurans - pharmacology; Derivatives; Drug Evaluation, Preclinical; Endophytes; Endophytes - chemistry; endophytic fungus; Enterobacter - drug effects; Fungi; Herbal medicine; Magnetic Resonance Spectroscopy; Medicinal plants; Microbial Sensitivity Tests; Minimum inhibitory concentration; Molecular Structure; NMR; Nuclear magnetic resonance; Penicillium; Penicillium - chemistry; Penicillium - isolation & purification; Penicillium sp; phthalide; Plants, Medicinal - microbiology; Shigella dysenteriae - drug effects; Sophora; Sophora - microbiology; Sophora tonkinensis; Penicillium sp; endophytic fungus; phthalide; Sophora tonkinensis
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1636237

Two new phthalide derivatives, (-)-3-carboxypropyl-7-hydroxyphthalide (1) and (-)-3-carboxypropyl-7-hydroxyphthalide methyl ester (2), were isolated from the endophytic fungus Penicillium vulpinum isolated from the Chinese medicinal plant Sophora tonkinensis. Their structures were elucidated using spectroscopic methods, mainly on 1D and 2D NMR. Compound 1 exhibited medium antibacterial activities against Bacillus subtilis, Shigella dysenteriae and Enterobacter areogenes with MIC values of 12.5-25 μg/mL, and 2 showed a medium inhibition to E. areogenes with MIC value of 12.5 μg/mL.