Cyclocarioside O-Q, three novel seco-dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus

• Published in: Natural product research Vol. 35; no. 1; pp. 167 - 173
• Main Authors: Xuan, Tong-Yao, Tan, Jie, Sun, Hui-Hui, Yang, Can, Lv, Wen-Yan, Zhang, Ji-Hua, Zhang, Ke-Qing, Nie, Ze-Qun, Ye, Zi-Jun, He, Xiao-Ai, Zhu, Gang-Zhi, Xu, Kang-Ping
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2021; Taylor & Francis Ltd
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; Cell Line, Tumor; Colon; Cyclocarya paliurus; Cytotoxic activities; Dammaranes; Drug Screening Assays, Antitumor; Gastric cancer; Glycosides; Glycosides - chemistry; HCT116 Cells; Hep G2 Cells; Hepatocellular carcinoma; Humans; Juglandaceae - chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; NMR; Nuclear magnetic resonance; Pancreas; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Plant Leaves - chemistry; Seco-dammarane triterpenoid glycosides; Triterpenes - chemistry; Triterpenes - pharmacology; Triterpenoid glycosides; Tumor cell lines; Tumor cells; Tumors; Seco-dammarane triterpenoid glycosides; Cyclocarya paliurus; Cytotoxic activities
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2019.1616722

Three previously undescribed seco-dammarane triterpenoid glycosides O-Q (1-3) along with two known compounds (4 and 5) were isolated and characterized from the leaves of Cyclocarya paliurus. Their structures were determined by comprehensive analysis of 1 D, 2 D NMR and HRESIMS data. Compounds 1-5 were evaluated for their inhibitory effects against human pancreatic tumor (ASPC-1), human gastric carcinoma (SNU5), liver hepatocellular carcinoma (HEPG-2) and human colon tumor (HCT116) cell lines. Among them cyclocarioside P (2) showed somewhat inhibitory activity towards those tumor cells.