Chemical constituents, Antibacterial and Acetylcholine esterase inhibitory activity of Cupressus macrocarpa leaves

• Published in: Natural product research Vol. 34; no. 6; pp. 816 - 822
• Main Authors: Harraz, Fathalla M., Hammoda, Hala M., El-Hawiet, Amr, Radwan, Mohamed M., Wanas, Amira S., Eid, Asmaa M., ElSohly, Mahmoud A
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 18.03.2020; Taylor & Francis Ltd
• Subjects: Acetylcholinesterase; acetylcholinesterase inhibitory activity; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Cholinesterase Inhibitors - isolation & purification; Cholinesterase Inhibitors - pharmacology; Constituents; Cupressus - chemistry; Cupressus macrocarpa; Drug resistance; Esterase; Glycosides - isolation & purification; Glycosides - pharmacology; Lignans - isolation & purification; Lignans - pharmacology; Methicillin; methicillin-resistant Staphylococcus aureus; Methicillin-Resistant Staphylococcus aureus - drug effects; neolignan glycoside; Plant Extracts - chemistry; Plant Leaves - chemistry; Staphylococcus aureus; Staphylococcus infections; acetylcholinesterase inhibitory activity; antibacterial activity; methicillin-resistant Staphylococcus aureus; neolignan glycoside; Cupressus macrocarpa
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2018.1508140

The chemical constituents of Cupressus macrocarpa were investigated. A new neolignan glycoside (1) in addition to nine known compounds were isolated. The acetylcholinesterase (AChE) inhibitory activity and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) of different fractions and isolates of C. macrocarpa were evaluated. The light petroleum fraction showed the highest activity in both assays with IC 50 value of 88.79 µg/ml and 152.58 µg/ml for the AChE inhibitory activity and MRSA antibacterial activities, respectively. Weak to moderate activity were detected for the isolated compounds.