Intubation at Birth Is Associated with Death after Pulmonary Hemorrhage in Very Low Birth Weight Infants

• Published in: Children (Basel) Vol. 11; no. 6; p. 621
• Main Authors: Sun, Yong-Ping, Qin, Hou-Bing, Feng, Yun, Zou, Yun-Su, Liu, Yun, Cheng, Rui, Yang, Yang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.05.2024; MDPI
• Subjects: Apgar score; Birth weight; Caffeine; Congenital diseases; Drug dosages; Gestational age; Hemorrhage; Hospitalization; Infants (Premature); Intubation; Lung diseases; mechanical ventilation; Mortality; Neonatology; Newborn babies; Nonsteroidal anti-inflammatory drugs; Pediatric respiratory diseases; postnatal tracheal intubation; Premature babies; Premature birth; preterm infants; Pulmonary arteries; pulmonary hemorrhage; Regression analysis; Respiratory diseases; Respiratory distress syndrome; risk factor; Sepsis; Surfactants; Ventilators; China; pulmonary hemorrhage; postnatal tracheal intubation; mechanical ventilation; preterm infants; risk factor
• ISSN: 2227-9067; 2227-9067
• DOI: 10.3390/children11060621

This retrospective cohort study was performed to clarify the association between intubation in the delivery room and the mortality after pulmonary hemorrhage in very low birth weight infants (VLBWIs) during hospitalization. The study participants were screened from the VLBWIs admitted to the neonatal intensive care unit (NICU) of the Children's Hospital Affiliated to Nanjing Medical University from 31 July 2019 to 31 July 2022. The newborns who ultimately were included were those infants who survived until pulmonary hemorrhage was diagnosed. These subjects were divided into the intubation-at-birth group ( = 29) and the non-intubation-at-birth group ( = 35), retrospectively. Univariate analysis found that the intubation group had a higher mortality and shorter hospital stay than the non-intubation group ( < 0.05) (for mortality: 25/29 (86.21%) in intubation group versus 14/35 (40.00%) in non-intubation group). By multivariate analysis, the result further showed that intubation in the delivery room was related to shorter survival time and higher risk of death (adjusted hazard ratio: 2.341, 95% confidence interval: 1.094-5.009). Intubation at birth suggested a higher mortality in the VLBWIs when pulmonary hemorrhage occurred in the NICU.